TB-500

A synthetic fragment of the body's own protein thymosin beta-4, studied in preclinical research on cell migration and tissue regeneration.

TB-500 is the synthetically produced, seven-amino-acid core sequence of the body's own protein thymosin beta-4. Most available data, including clinical studies, relate to the full 43-amino-acid thymosin beta-4, not to the isolated TB-500 fragment itself. Areas of study include cell migration, angiogenesis, and a possible role in hair follicle activation.

Facts

• Molecular weight: 4963 g/mol
• Amino acids: 43
• Purity specification: ≥ 99 % (HPLC, commercial standard)

Evidence

• A study in rats and mice described that the active sequence of thymosin beta-4, which also forms TB-500, influenced stem cell migration within the hair follicle. Philp et al. 2004, FASEB Journal, PMID 14657002
• A randomized, placebo-controlled clinical trial in patients with severe dry eye tested an eye-drop formulation of the full thymosin beta-4 protein and described improved signs and symptoms compared with placebo. The trial involved the full protein, not the TB-500 fragment itself. Sosne et al. 2015, Cornea, PMID 25826322

Frequently asked questions

Is TB-500 the same as thymosin beta-4?
No. TB-500 is a synthetic seven-amino-acid fragment of the full 43-amino-acid thymosin beta-4 sequence. Most clinical data relate to the full protein, not the fragment.

Are there clinical studies on TB-500 itself?
No independent controlled human studies on the isolated TB-500 fragment are available. Available clinical data come from the full thymosin beta-4 protein.

Is TB-500 relevant to anti-doping rules?
Thymosin beta-4 and related fragments are on the World Anti-Doping Agency prohibited list.

Documented prices

List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.