Thymosin Alpha 1

A naturally occurring thymus-derived immune peptide, approved as a medication in more than 35 countries, though not currently in Germany, Austria, or Switzerland.

Thymosin alpha 1 is a 28-amino-acid peptide originally isolated from the thymus gland, the central organ where T cells mature. It acts as an immune modulator and is used both in clinical research and, under the trade name Zadaxin, as an approved medication for certain immune conditions. Areas of study include chronic viral infections, the immune response to vaccination, and a supportive role in oncology.

Facts

• CAS number: 62304-98-7
• Molecular weight: 3108.3 g/mol
• Amino acids: 28
• Purity specification: ≥ 98 % (HPLC, commercial standard)

Evidence

• A retrospective review of 76 patients with severe COVID-19 across two hospitals described lower mortality under thymosin alpha 1 compared with the untreated group, accompanied by a recovery of T-cell counts. Liu et al. 2020, Clinical Infectious Diseases
• A randomized trial in 42 patients with non-small cell lung cancer after radiation described faster normalization of T-cell function under thymosin alpha 1 versus placebo, along with a survival benefit, most pronounced in patients with smaller tumors. Schulof et al. 1985, Journal of Biological Response Modifiers, PMID 3998766

Frequently asked questions

Is thymosin alpha 1 an approved medication?
Yes, under the trade name Zadaxin in more than 35 countries, including for chronic hepatitis B and C. There is currently no approval in Germany, Austria, or Switzerland.

What does thymosin alpha 1 act on in the immune system?
It acts on both the innate and the adaptive immune system at once, including through increased activity of T cells and natural killer cells, and improved antibody formation.

Are there human studies on thymosin alpha 1?
Yes, compared with many other peptides there is a broader base of clinical studies, including work on severe viral infections, a supportive role in cancer care, and vaccine response.

Documented prices

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