5-Amino-1MQ

A small molecule and selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), studied to date exclusively in preclinical animal models related to fat metabolism.

5-Amino-1MQ is not a peptide but a small molecule, a selective, orally bioavailable inhibitor of nicotinamide N-methyltransferase (NNMT). It has a molecular weight of 173.21 Da, and research batches sold commercially typically carry a purity of at least 98 percent. It is listed under the metabolism category because NNMT is involved in energy metabolism in adipose tissue and muscle. To date, only preclinical data from rodent models are available, and no controlled human studies are known.

Facts

• CAS number: 685079-15-6
• Molecular weight: 159.21 g/mol
• Purity specification: ≥ 98 % (HPLC, commercial standard)

Evidence

• In a mouse model with genetic knockdown of NNMT in adipose tissue, protection against diet-induced obesity was observed compared to control animals, along with increased energy expenditure. Kraus D et al. 2014, Nature 508:258-262, PMID 24717514
• In diet-induced obese mice, eleven days of 5-Amino-1MQ administration reduced body weight, fat mass, and adipocyte size compared to control animals, without altering food intake. Neelakantan H et al. 2018, Biochemical Pharmacology, PMID 29155147
• In aged mice, an NNMT inhibitor was associated with reactivation of senescent muscle stem cells and improved regenerative capacity of skeletal muscle after injury. Neelakantan H et al. 2019, Biochemical Pharmacology 163:481-492
• Combining a reduced-calorie diet with 5-Amino-1MQ normalized body fat percentage and weight faster in diet-induced obese mice than diet change alone, while also altering gut microbiome composition. Scientific Reports 2022, PMID 35013352

Frequently asked questions

Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small molecule, not a peptide, and does not consist of an amino acid chain. It is studied as a selective inhibitor of the NNMT enzyme and listed here among metabolism-related compounds because it acts on related target systems.

Are there human studies on 5-Amino-1MQ?
No, no controlled clinical studies in humans are known to date. All published data come from preclinical research in mice.

Why is NNMT studied in research?
NNMT is an enzyme active in adipose tissue and muscle that breaks down nicotinamide, a precursor of NAD+. Elevated NNMT levels have been linked to reduced metabolic activity in preclinical models, which is why its inhibition is being studied as a research approach.

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