Tirzepatid

A dual GIP/GLP-1 receptor agonist, known as an approved medication and listed here as a research substance for metabolic regulation.

Tirzepatide is a dual GIP/GLP-1 receptor agonist approved as a medication under the names Mounjaro and Zepbound. It is the subject of extensive clinical research on metabolic and weight regulation in type 2 diabetes and obesity. The research batches listed here are not equivalent to approved medications and are intended for laboratory use only.

Facts

• CAS number: 2023788-19-2
• Molecular weight: 4813 g/mol
• Amino acids: 39
• Halbwertszeit: ≈ 5 days (elimination, Mounjaro prescribing information)
• Purity specification: ≥ 99 % (HPLC, commercial standard)

Evidence

• In a randomized trial with 2,539 adults with obesity or overweight, weekly tirzepatide over 72 weeks led to a mean body weight loss of up to 20.9 percent (15 mg) versus 3.1 percent under placebo. Jastreboff AM et al. 2022, New England Journal of Medicine, PMID 35658024
• In a randomized head-to-head trial with 1,879 people with type 2 diabetes, tirzepatide lowered HbA1c by 2.09 to 2.46 percentage points and body weight by 7.8 to 12.4 kg after 40 weeks, in each case more than semaglutide 1 mg. Frías JP et al. 2021, New England Journal of Medicine, PMID 34170647

Frequently asked questions

Is tirzepatide an approved medication?
Yes, tirzepatide is approved as a prescription medication under the names Mounjaro and Zepbound. The substance described here is a research batch only, not a finished pharmaceutical product.

How does tirzepatide differ from semaglutide?
Semaglutide acts only on the GLP-1 receptor, while tirzepatide additionally acts on the GIP receptor. In a head-to-head trial, tirzepatide showed larger effects on HbA1c and body weight than semaglutide.

What is tirzepatide used for as a medication?
As an approved medication, tirzepatide is prescribed for type 2 diabetes and weight management. This page describes the substance exclusively as a research chemical for laboratory purposes.

Documented prices

List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.