Peptide Compass · Research
Dihexa: research, prices and suppliers
A synthetic angiotensin IV analog studied in preclinical rat models of memory function, with no published human data to date.
Dihexa is a synthetic peptidomimetic derived from the body's own angiotensin IV, developed in Joseph Harding's research group at Washington State University. To date it has been studied exclusively in preclinical models, mainly rats, in connection with learning and memory performance. No published human studies exist for dihexa, so its safety profile in humans has not been examined.
Facts
- CAS number: 1401708-83-5
- Molecular weight: 504.7 g/mol
- Amino acids: 2
Evidence
- In rats, orally administered dihexa reversed scopolamine-induced memory deficits in the Morris water maze test and improved learning in 24-month-old animals. McCoy AT et al. 2013, Journal of Pharmacology and Experimental Therapeutics, PMID 23055539 (This paper has carried an Expression of Concern from the publisher since 2021 over possible image manipulation, no retraction)
- In a rat model of 3-nitropropionic acid-induced Huntington's-like symptoms, PNB-0408 (dihexa) showed no significant improvement in motor or neuropathological endpoints compared to control animals. Wells RG et al. 2024, Journal of Huntington's Disease, Bd. 13, Nr. 1, S. 55-66, PMID 38489193
Frequently asked questions
Are there any human studies on dihexa
No. All data published on dihexa to date come from animal models, mainly rats. A safety profile for human use has not been examined, so neither tolerability nor efficacy data in humans exist.
How is dihexa's mechanism of action explained
Dihexa is reported to bind to the hepatocyte growth factor receptor c-Met, a pathway proposed to trigger synaptogenesis in cell models. Part of the work that originally supported this mechanism was retracted in 2025 due to falsified data.
Is dihexa an approved medication
No. Dihexa has never entered a clinical approval process for human use and is not approved as a medication in Germany, the EU, or the United States. It is sold exclusively as a research chemical.
Documented prices
Prices are recorded snapshots. Each entry states its date, currency and pack variant. Shipping, tax treatment, discount conditions and availability must be rechecked in the shop. A low price is not evidence of quality.
List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.
| Vendor | Pack | List price | Price/mg | Recorded | Source |
|---|---|---|---|---|---|
| Peptide Shop Deutschland | 10 mg | 59.99 EUR | 6.0 EUR/mg | 2026-09-15 | Product page · Ad |
| American Peptides | 5 mg | 140 USD | 28.0 USD/mg | 2026-09-15 | Product page · Ad |
Questions about interpretation
What does the search “Dihexa protocol” mean?
“Protocol” is often used to mean a regimen. This page explains research and documented listings. It contains no doses, cycles or instructions for human use. An online regimen is not scientifically validated simply because it is widely shared.
Sources and data basis
These references come from the existing dataset. A link alone verifies neither a study claim nor supplier quality. Uncertainty remains explicit where records are undated or incomplete.
- McCoy AT et al. 2013, Journal of Pharmacology and Experimental Therapeutics, PMID 23055539 (This paper has carried an Expression of Concern from the publisher since 2021 over possible image manipulation, no retraction)
- Wells RG et al. 2024, Journal of Huntington's Disease, Bd. 13, Nr. 1, S. 55-66, PMID 38489193
- PMID 23055539
- PMID 38489193
Where to go next
Created with AI assistance. This new edition has not yet received independent editorial review.