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Peptide Compass · Research

DSIP: research, prices and suppliers

One of the longest-studied neuropeptides, originally isolated as a sleep-inducing messenger from the brain of sleeping rabbits, with an inconsistent body of research to this day.

Sources and dates are stated with individual entries. This new presentation is not a complete re-investigation of all data.

DSIP (delta sleep-inducing peptide) is a nonapeptide first isolated in 1977 by Schoenenberger and Monnier from the venous brain blood of sleeping rabbits and named for its ability to trigger delta-wave EEG activity in that animal model. Over the following decades it was studied in numerous human trials on sleep, the stress axis, and hormone regulation. The originally described sleep-promoting effect has not been reliably reproduced in independent, more rigorous studies.

Facts

  • CAS number: 62568-57-4
  • Molecular weight: 848.8 g/mol
  • Amino acids: 9
  • Purity specification: ≥ 98 % (HPLC, commercial standard)

Evidence

  • The original isolation from the brain blood of sleeping rabbits identified the nonapeptide sequence and showed increased delta-wave EEG activity in the animal model following intraventricular administration. Schoenenberger GA, Monnier M 1977, Proceedings of the National Academy of Sciences, Bd. 74(3), S. 1282-1286, PMID 265572
  • In a double-blind crossover study in chronic insomnia patients with polysomnographic monitoring over four nights, sleep improvement under DSIP was minor compared to placebo. Monti JM et al. 1987, International Journal of Clinical Pharmacology Research, Bd. 7(2), S. 105-110, PMID 3583493
  • A review summarizing three decades of human and animal research concludes that the originally postulated sleep-inducing effect of DSIP could not be consistently confirmed in independent studies. Kovalzon VM, Strekalova TV 2006, Journal of Neurochemistry, Bd. 97(2), S. 303-309, PMID 16539679
  • A 2024 preclinical study examined a DSIP fusion peptide in a mouse model of pharmacologically induced insomnia and described effects on neurotransmitter levels such as serotonin and dopamine. Mu X et al. 2024, Frontiers in Pharmacology, Bd. 15, Artikel 1439536, PMID 39444618

Frequently asked questions

Has the sleep-promoting effect of DSIP been confirmed in studies


The evidence is inconsistent. Early studies reported sleep-promoting effects, but a 2006 review concluded that this effect could not be consistently reproduced in independent studies.

Where does the name DSIP come from


DSIP stands for delta sleep-inducing peptide. The name traces back to its first description in 1977, when it was isolated from the brain blood of sleeping rabbits and triggered delta-wave EEG activity in that animal model.

Is DSIP legally available in Germany


DSIP is not approved as a medication in Germany or the EU. It is offered exclusively as a research chemical for laboratory purposes, not for human use.

Documented prices

Prices are recorded snapshots. Each entry states its date, currency and pack variant. Shipping, tax treatment, discount conditions and availability must be rechecked in the shop. A low price is not evidence of quality.

List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.

VendorPackList pricePrice/mgRecordedSource
Europa-Peptide5 mg29.9 EUR5.98 EUR/mg2026-09-15Product page · Ad
Smart Peptides5 mg29.9 EUR5.98 EUR/mg2026-09-15Product page · Ad
Peptide Shop Deutschland5 mg29.99 EUR6.0 EUR/mg2026-09-15Product page · Ad
Beyond Peptides5 mg37.22 EUR7.44 EUR/mg2026-09-15Product page · Ad
Peptide Labz5 mg40 EUR8.0 EUR/mg2026-09-15Product page · Ad
DN Lab Research5 mg55 EUR11.0 EUR/mg2026-09-15Product page · Ad
Peak Peptide10 mg49.9 EUR4.99 EUR/mg2026-09-15Product page · Ad
Smart Peptides10 mg49.9 EUR4.99 EUR/mg2026-09-15Product page · Ad
Peptidwerk10 mg49.95 EUR5.0 EUR/mg2026-09-15Product page · Ad
Particle Peptides10 mg49.99 EUR5.0 EUR/mg2026-09-15Product page · Ad
Europa-Peptide10 mg54.9 EUR5.49 EUR/mg2026-09-15Product page · Ad
Peptide Labz10 mg65 EUR6.5 EUR/mg2026-09-15Product page · Ad
Peptide Shop Deutschland10 mg68 EUR6.8 EUR/mg2026-09-15Product page · Ad
Bio BoostX15 mg59.95 EUR4.0 EUR/mg2026-09-15Product page · Ad
Smart Peptides15 mg64.9 EUR4.33 EUR/mg2026-09-15Product page · Ad
Licensed Peptides5 mg53.99 USD10.8 USD/mg2026-09-15Product page · Ad
American Peptides5 mg55 USD11.0 USD/mg2026-09-15Product page · Ad
Protide Health5 mg60 USD12.0 USD/mg2026-09-15Product page · Ad
Chameleon Peptides10 mg47.7 USD4.77 USD/mg2026-09-15Product page · Ad
Protide Health10 mg100 USD10.0 USD/mg2026-09-15Product page · Ad
Chameleon Peptides15 mg60.3 USD4.02 USD/mg2026-09-15Product page · Ad

Questions about interpretation

What does the search “DSIP protocol” mean?

“Protocol” is often used to mean a regimen. This page explains research and documented listings. It contains no doses, cycles or instructions for human use. An online regimen is not scientifically validated simply because it is widely shared.

Sources and data basis

These references come from the existing dataset. A link alone verifies neither a study claim nor supplier quality. Uncertainty remains explicit where records are undated or incomplete.

Where to go next

Created with AI assistance. This new edition has not yet received independent editorial review.