Epitalon

A synthetic tetrapeptide, studied in aging research as a research substance related to cellular aging.

Epitalon is a synthetic tetrapeptide developed by Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. It is studied in preclinical research in connection with cellular aging and the regulation of telomerase activity. Robust clinical data in humans is still pending.

Facts

• CAS number: 307297-39-8
• Molecular weight: 390.35 g/mol
• Amino acids: 4
• Purity specification: ≥ 98 % (HPLC, commercial standard)

Evidence

• In human fetal fibroblast cell cultures, epitalon induced expression of the catalytic telomerase subunit and measurable telomerase activity, associated with telomere elongation. Khavinson VKh, Bondarev IE, Butyugov AA 2003, Bulletin of Experimental Biology and Medicine 135:590-592
• In animal models, effects of epitalon on melatonin release and on immune system parameters have been described, with mixed results on lifespan depending on the model and protocol used. Khavinson VKh, Morozov VG 2003, Neuroendocrinology Letters

Frequently asked questions

Has epitalon been studied in humans?
Available data come predominantly from cell culture and animal models. Controlled clinical studies in humans meeting Western standards are not yet available.

What does epitalon have to do with telomeres?
Cell culture studies observed an increase in telomerase activity and telomere elongation. Whether this translates to the whole organism remains open.

Is epitalon legally available in Germany?
Epitalon is not approved as a medication and is offered exclusively as a research chemical, not for human use.

Documented prices

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