Semaglutid

A GLP-1 receptor agonist, known as an approved medication and listed here as a research substance for metabolic regulation.

Semaglutide is a GLP-1 receptor agonist approved as a medication under several brand names. It is the subject of extensive clinical research on metabolic and satiety regulation. The research batches listed here are not equivalent to approved medications and are intended for laboratory use only.

Facts

• CAS number: 910463-68-2
• Molecular weight: 4114 g/mol
• Amino acids: 31
• Halbwertszeit: ≈ 1 week (elimination, Ozempic prescribing information)
• Purity specification: ≥ 99 % (HPLC, commercial standard)

Evidence

• In a randomized trial with 1,961 adults with overweight or obesity, weekly semaglutide over 68 weeks led to a mean body weight loss of 14.9 percent versus 2.4 percent under placebo. Wilding JPH et al. 2021, New England Journal of Medicine, PMID 33567185
• In a cardiovascular outcomes trial with 3,297 people with type 2 diabetes and elevated cardiovascular risk, semaglutide was associated with a 26 percent lower rate of major cardiovascular events compared to placebo. Marso SP et al. 2016, New England Journal of Medicine 375:1834-1844, PMID 27633186

Frequently asked questions

Is semaglutide an approved medication?
Yes, semaglutide is approved as a prescription medication under the names Ozempic, Wegovy, and Rybelsus. The substance described here is a research batch only, not a finished pharmaceutical product.

How does semaglutide differ from retatrutide?
Semaglutide acts only on the GLP-1 receptor, while retatrutide additionally acts on the GIP and glucagon receptors. Retatrutide is also still in phase 3 trials, while semaglutide is already approved.

What is semaglutide used for as a medication?
As an approved medication, semaglutide is prescribed for type 2 diabetes and weight management. This page describes the substance exclusively as a research chemical for laboratory purposes.

Documented prices

List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.