Peptide Compass · Research

Cagrilintide: research, prices and suppliers

A long-acting analogue of the body's own hormone amylin, studied in clinical trials for metabolic and satiety regulation, alone and in combination with semaglutide.

Sources and dates are stated with individual entries. This new presentation is not a complete re-investigation of all data.

Cagrilintide is a long-acting amylin analogue developed by Novo Nordisk. It is being studied both as a standalone substance and in a fixed combination with the GLP-1 compound semaglutide, marketed under the name CagriSema, in phase 3 trials. To date, cagrilintide is not approved as a standalone medication in any country.

Facts

CAS number: 1415456-99-3
Molecular weight: 4409 g/mol
Amino acids: 37
Purity specification: ≥ 98 % (HPLC, commercial standard)

Evidence

In a randomized phase 2 trial testing several amounts in 706 adults with overweight or obesity, cagrilintide alone over 26 weeks led to a mean body weight loss of 10.8 percent at the highest amount tested, compared with around 3 percent under placebo. Lau DCW et al. 2021, The Lancet 398:2160-2172, PMID 34798060
In the phase 3 REDEFINE 1 trial, the cagrilintide-alone arm at 2.4 mg weekly achieved a body weight loss of around 11.8 percent after 68 weeks, compared with 2.3 percent under placebo. Garvey WT et al. 2025, New England Journal of Medicine 393:625-638, PMID 40544433
In a diet-induced obesity mouse model, cagrilintide's body-weight-lowering effect depended on the brain amylin receptors AMY1 and AMY3, and the effect was absent in receptor knockout animals. Carvas AO et al. 2025, eBioMedicine, PMID 40609154
Structural optimization with fatty-acid lipidation gave cagrilintide a substantially longer half-life of about 159 to 195 hours than the body's own hormone amylin, allowing once-weekly administration in the trial setting. Kruse T et al. 2021, Journal of Medicinal Chemistry 64:11183-11194, PMID 34288673

Frequently asked questions

Is cagrilintide already available as a medication?

No. Cagrilintide is being studied as a standalone substance and in the CagriSema combination in phase 3 trials. An FDA approval process for CagriSema has been underway since December 2025. Cagrilintide is currently not an approved medication.

What sets cagrilintide apart from semaglutide?

Semaglutide acts on the GLP-1 receptor, while cagrilintide acts on amylin receptors in the brain. Both compounds are also studied as a fixed combination called CagriSema, which showed a greater effect on body weight in trials than either substance alone.

Where does cagrilintide come from?

Cagrilintide was developed by the pharmaceutical company Novo Nordisk, which also developed semaglutide. It is referenced under the short designations AM833 and NN9838 in clinical trials, including the REDEFINE trial program.

Documented prices

Prices are recorded snapshots. Each entry states its date, currency and pack variant. Shipping, tax treatment, discount conditions and availability must be rechecked in the shop. A low price is not evidence of quality.

List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.

Vendor	Pack	List price	Price/mg	Recorded	Source
Peptide Shop Deutschland	5 mg	54.99 EUR	11.0 EUR/mg	2026-09-15	Product page · Ad
Peptidwerk	5 mg	69.95 EUR	13.99 EUR/mg	2026-09-15	Product page · Ad
Driada	10 mg	59 EUR	5.9 EUR/mg	2026-09-15	Product page · Ad
Europa-Peptide	10 mg	69 EUR	6.9 EUR/mg	2026-09-15	Product page · Ad
Bio BoostX	10 mg	69.95 EUR	7.0 EUR/mg	2026-09-15	Product page · Ad
Peptidwerk	10 mg	89.95 EUR	9.0 EUR/mg	2026-09-15	Product page · Ad
Protide Health	5 mg	95 USD	19.0 USD/mg	2026-09-15	Product page · Ad
Licensed Peptides	5 mg	107.99 USD	21.6 USD/mg	2026-09-15	Product page · Ad
Protide Health	10 mg	155 USD	15.5 USD/mg	2026-09-15	Product page · Ad
American Peptides	10 mg	170 USD	17.0 USD/mg	2026-09-15	Product page · Ad

Questions about interpretation

What does the search “Cagrilintide protocol” mean?

“Protocol” is often used to mean a regimen. This page explains research and documented listings. It contains no doses, cycles or instructions for human use. An online regimen is not scientifically validated simply because it is widely shared.

Sources and data basis

These references come from the existing dataset. A link alone verifies neither a study claim nor supplier quality. Uncertainty remains explicit where records are undated or incomplete.

Where to go next

Created with AI assistance. This new edition has not yet received independent editorial review.