Peptide Compass · Research
PT-141 (Bremelanotide): research, prices and suppliers
A synthetic heptapeptide and melanocortin receptor agonist, approved in the US under the name Vyleesi for a specific form of low sexual desire in women.
PT-141 (bremelanotide) is a seven-amino-acid peptide developed at Palatin Technologies as a follow-on compound to melanotan II. Unlike melanotan II, which was studied mainly for skin pigmentation, research on bremelanotide focused on the central regulation of sexual desire. Since 2019, the compound has been approved in the US under the name Vyleesi for the indication hypoactive sexual desire disorder (HSDD) in premenopausal women.
Facts
- CAS number: 189691-06-3
- Molecular weight: 1025.2 g/mol
- Amino acids: 7
- Half-life: ≈ 2.7 hours (terminal half-life, Vyleesi prescribing information)
- Purity specification: ≥ 99 % (HPLC, commercial standard)
Evidence
- Studies in female rats showed increased sexual solicitation behavior after bremelanotide administration, mediated by dopamine release following activation of MC4 receptors in the medial preoptic area of the hypothalamus. Pfaus JG et al. 2007, The Journal of Sexual Medicine, PMID 17958619
- In two randomized, placebo-controlled phase 3 trials (RECONNECT) in premenopausal women with HSDD, bremelanotide improved sexual desire and related distress more than placebo. Kingsberg SA, Clayton AH, Portman D et al. 2019, Obstetrics & Gynecology, PMID 31599840
- A pooled analysis of 43 clinical studies with roughly 3,500 participants documented nausea, flushing, headache, and transient blood pressure increases as the most common adverse effects of bremelanotide. Clayton AH et al. 2022, Journal of Women's Health, PMID 35147466
Frequently asked questions
Is PT-141 the same as melanotan II
No. Both trace back to related melanocortin structures, but PT-141 (bremelanotide) was specifically studied for sexual desire, while melanotan II was researched mainly for skin pigmentation. Only bremelanotide reached market approval in the US, as Vyleesi.
Is bremelanotide an approved medication
In the US, yes: since 2019 bremelanotide has been approved under the name Vyleesi for the indication of HSDD in premenopausal women. In Germany and the EU, no drug approval exists, and the substance is classed as a research chemical there.
What side effects were observed in studies
The most frequently documented effects were nausea, flushing, headache, and transient blood pressure increases after administration. According to the FDA label, the substance is contraindicated in uncontrolled hypertension or known cardiovascular disease.
Documented prices
Prices are recorded snapshots. Each entry states its date, currency and pack variant. Shipping, tax treatment, discount conditions and availability must be rechecked in the shop. A low price is not evidence of quality.
List prices excluding shipping and discounts. Currency and product variants must be compared separately. Availability and delivered batch have not been verified.
| Vendor | Pack | List price | Price/mg | Recorded | Source |
|---|---|---|---|---|---|
| DN Lab Research | 5 mg | 135 EUR | 27.0 EUR/mg | 2026-09-15 | Product page · Ad |
| Driada | 10 mg | 26 EUR | 2.6 EUR/mg | 2026-09-15 | Product page · Ad |
| Peptidwerk | 10 mg | 32.95 EUR | 3.3 EUR/mg | 2026-09-15 | Product page · Ad |
| Europa-Peptide | 10 mg | 34.9 EUR | 3.49 EUR/mg | 2026-09-15 | Product page · Ad |
| Peptide Labz | 10 mg | 35 EUR | 3.5 EUR/mg | 2026-09-15 | Product page · Ad |
| Beyond Peptides | 10 mg | 38.95 EUR | 3.9 EUR/mg | 2026-09-15 | Product page · Ad |
| Bio BoostX | 10 mg | 39.95 EUR | 4.0 EUR/mg | 2026-09-15 | Product page · Ad |
| Peptide Shop Deutschland | 10 mg | 39.99 EUR | 4.0 EUR/mg | 2026-09-15 | Product page · Ad |
| Peptide Shop Deutschland | 10 mg | 49 EUR | 4.9 EUR/mg | 2026-09-15 | Product page · Ad |
| Particle Peptides | 10 mg | 49.99 EUR | 5.0 EUR/mg | 2026-09-15 | Product page · Ad |
| Chameleon Peptides | 10 mg | 29 USD | 2.9 USD/mg | 2026-09-15 | Product page · Ad |
| BioCollex | 10 mg | 45 USD | 4.5 USD/mg | 2026-09-15 | Product page · Ad |
| Protide Health | 10 mg | 55 USD | 5.5 USD/mg | 2026-09-15 | Product page · Ad |
| American Peptides | 10 mg | 60 USD | 6.0 USD/mg | 2026-09-15 | Product page · Ad |
| Licensed Peptides | 10 mg | 87.99 USD | 8.8 USD/mg | 2026-09-15 | Product page · Ad |
Questions about interpretation
What does the search “PT-141 (Bremelanotide) protocol” mean?
“Protocol” is often used to mean a regimen. This page explains research and documented listings. It contains no doses, cycles or instructions for human use. An online regimen is not scientifically validated simply because it is widely shared.
Sources and data basis
These references come from the existing dataset. A link alone verifies neither a study claim nor supplier quality. Uncertainty remains explicit where records are undated or incomplete.
Where to go next
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